DNArepair相关论文
Objective SET8 is a member of the SET domain-containing family and the only known lysine methyltransferase (KMT) that mo......
目的:探讨GNG4与卵巢癌顺铂耐药A2780/DDP细胞DNA损伤修复及化疗敏感性的关系。方法:将A2780/DDP细胞分为500 ng/ml顺铂作用组（cDDP......
Roles of MEM1 in safeguarding Arabidopsis genome against DNA damage,inhibiting ATM/SOG1-mediated DNA
Arabidopsis methylation elevated mutant 1 (mem1)mutants have elevated levels of global DNA meth-ylation.In this study,su......
Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunothera
Genomic instability remains an enabling feature of cancer and promotes malignant transfor-mation.Alterations of DNA dama......
Ionizing irradiation (IR) can produce clustered DNA damages, particularly double-strand DNA breaks (DSBs) in the organis......
Radiotherapy eliminates tumor cells but has untoward effects on neighboring normal tissues including bone,causing acute ......
Two common genetic polymorphisms of xeroderma pigmentosum group D gene and susceptibility to prostat
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Prognostic implication and poor clinicopathological features of elevated Rad50 expression in prostat
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Objective Philadelphia(Ph)chromosome is the hallmark chromosome aberration in CML which confers the cancer phenotype of ......
Aim: RPA2 is a subunit of a trimeric RPA complex important for DNA repair and replication.Although it is known that RPA ......
Molecular basis of eIF3a action in therapeutic response of lung cancer patients to platinum-based ch
eIF3a is the largest subunit of eukaryotic translation initiation factor 3 (eIF3) that has been suggested to play a role......
ERCC1 C8092A and XRCC1 Arg399Gln Polymorphisms predict progression-free survival in nasopharyngeal c
Background: Single nucleotide polymorphisms (SNPs) in DNA repair genes may alter gene expression and activity and affect......
Base-flipping dynamics from an intrahelical to an extrahelical state exerted by thymine DNA glycosyl
Thymine DNA glycosylase(TDG)is a DNA repair enzyme that excises a variety of mismatched or damaged nucleotides(nt),e.g.,......
OBJECTIVE To investigate the role of elF3a in the regulation of DNA repair pathways in cancer chemotherapeutic response.......
Cranial radiation therapy can induce cognitive decline.Impairments of hippocampal neurogenesis are thought to be a param......
Chemotherapy is a main category of cancer treatment that aims to prolong life or to reduce symptoms.Besides blocking cel......
Deamination of cytosine or incorporation of dUMP during DNA replication leads to uracil incorporation and DNA damage.Ura......
DNA-PKcs is an important molecule of non-homologous end joining repair of double strand breaks.Once DNA double strand br......
Protective Effect and Mechanism of Wu-Zi-Yan-Zong-Fang on Cyclophosphamide Induced DNA Damage in Liv
Aim: To investigate protective effect and mechanism of Wu-Zi-Yan-Zong-Fang against cyclophosphamide induced DNA damage o......
Low dose/ low LET radiation-induced adaptive response (LIAR), one of main challenges to classic biological dose-response......
NUCLEOLIN PARTICIPATES IN DNA DOUBLE-STRAND BREAK-INDUCED DAMAGE RESPONSE THROUGH MDC1-DEPENDENT PAT
H2AX is an important factor for chromatin remodeling to facilitate accumulation of DNA damage-related proteins at DNA do......
The different biological effects of single, fractionated and continuous low dose rate irradiation on
Purpose: To determine the biological effectiveness of single, fractionated and continuous low dose rate irradiation on t......
The Translationally Controlled Tumor Protein (TCTP) is a highly conserved protein that is widely expressed in all eukary......
Molecular basis of eIF3a action in therapeutic response of lung cancer patients to platinum-based ch
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Direct Effects of 125I Seeds Radiation on A549 Lung Cancer Cells:G2/M Arrest and Enhanced Cell Death
Introduction External beam radiation (EBRT) and 125I seed continuous low dose rate radiation (CLDR)were used to treat pa......
Polymorphisms of Nucleotide-excision Repair Genes in Relation to Sperm DNA Fragmentation and Male In
Nucleotide-excision repair system is critical for the removal of bulky DNA adducts during spermatogenesis,and its dysfun......
The radiation protector homocysteine thiolactone induces cell proliferation but has no protective ef
Objectives Homocysteine thiolactone （HCTL） is a normal metabolite of amino acid metabolism，and has been proved as a potenti......
Association of Base Excision Repair Gene Polymorphisms with the Response to Chemotherapy in Advanced
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Effects of 3-aminobenzamide on expressions of poly(ADP ribose)polymerase and apoptosis inducing fact
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ObjectiveTo establish a model to predict the cell-cycle process in response to ionizing radiation.MethodsHuman choroidal......
面对各种因素导致的DNA损伤，细胞有一套应答修复机制。其中细胞周期阻滞在DNA损伤应答修复中扮演了重要角色，为修复受损DNA创造了条......
Epigenetic regulators have been implicated in tumorigenesis of many types of cancer;however,their roles in endothelial c......
Additive effect of DNA repair mechanisms on doxorubicin resistance of human breast adenocarcinoma MC
Drug resistance remains a limiting factor for the efficacy of cancer chemotherapy.DNA repair mechanisms maintain gen......
P27Modular organization and functional interaction with Hjc endonuclease of Hjm helicase from Sulfol
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Dysfunction of the DNA repair machinery, which may underlie genomic instability frequently observed in cancer, may play ......
Xbp1-mediated checkpoint regulation of histone H4 deacetylation contributes to DNA double-strand bre
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会议
Repair of DNA double-strand break (DSB) is critical for the maintenance of genome integrity.A class of DSB-induced small......
（１）目的观察牛磺权对小鼠脾细胞ＤＮＡ修复能力的影响，以探讨牛磺酸抗衰老的机制。（２）方法以不同鼠龄小白鼠脾细胞悬液进行培养，实验级培养液中加......
利用缺口修复（ｇａｐｒｅｐａｉｒ）方法克隆啤酒酵母（Ｓ．ｃｅｒｅｖｉｓｉａｅ）野生型ＲＡＤ２４基因，并将其亚克隆到Ｍ１３ｍｐ１８和Ｍ１３ｍｐ１９，用双脱氧末端终止法对该基因的两条链均进行了序列测定，ＤＮＡＳｔｒｉｄｅｒ程序分析显示该基......
在大鼠晶状体器官培养的条件下，运用单细胞电泳法（ＳＣＧ），对远在晶状体混浊之前的晶状体上皮细胞进行了有关ＴＮＴ致其ＤＮＡ损伤（ＳＳＢ）与修复的初步观察。提示......
目的 研究DNA修复酶基因NEIL1编码区发生的A-Ⅰ RNA编辑是否在正常和癌细胞或组织中存在差异,并分析编辑事件的潜在影响,初步探究N......
目的 观察燃煤污染型地方性砷中毒(简称燃煤型砷中毒)患者外周血中切除修复交叉互补基因1(ERCC1)mRNA和皮肤组织中ERCC1蛋白表达情......
目的观察贵州省燃煤污染型砷中毒病区砷暴露者外周血细胞组蛋白H4第20位赖氨酸（H4K20）甲基化修饰水平及其与血细胞DNA损伤的关系，为揭......
生物体基因组不断受到各种内外因素的威胁仍能保持遗传信息的稳定传递，与机体不同类型的DNA修复功能密切相关。但是，当DNA修复功能异......
目的 建立人类慢性粒细胞白血病(CML)细胞系K562细胞在伊马替尼(Imatinib mesylate)处理前、后的DNA损伤模型,探讨伊马替尼对K562......
目的 探讨DNA修复基因XRCCl多态与食管癌遗传易感性的关系.方法 采用病例一对照分子流行病学方法,分析182例食管癌病人和375例正常......
胶质瘤放化疗耐受现象的分子机制是一个多信号通路构成的复杂网络,近年来的研究表明细胞DNA损伤检控点ATM、ATR、Chk1、Chk2、Rad1......
